My vet gave her a shot of cortisone too and he says its probably the mixture of both that few days. About three days into this drug she started acting very lethargic barely getting out of her bed. Metronidazole (also known by the brand names Flagyl, Metizol, Protostat, Metrogel) is a strong antibiotic primarily used as an antidiarrheal to treat inflammation of the large intestine. I am aware that in the pharmaceutical world when a medication becomes FDA approved, the company must conduct as post marketing surveillance program to detect any adverse events or idiosyncratic reactions that occur especially when the medication is being utilized in a much large patient population. But I love my dogs and if this is what happens with using Apoquel. In humans, hydroxyzine is sometimes prescribed to treat anxiety. My vet says it is safe but will listen to me if I tell him about this which obviously I will. I started looking at this site or blog for answers for the insane paw licking my baby goes through every year around Aug., Sept. But it continued, the swelling, around the legs, his body was swollen, around his eyes. Im going to bed. Efficacy of dimetinden and hydroxyzine/chlorpheniramine in atopic dogs: a randomised, controlled, double-blinded trial, What To Do When Your Puppy Pees In The House, How Do You Potty Train A 4 Month Old Puppy, What To Do When Your Puppy Hates Leash Walking, How To Stop My Cockapoo Puppy From Biting, an increase of pruritus (if the drug is given in high doses), cardiovascular problems (particularly in the case of an overdose), US National Library of Medicine: MedlinePlus , Book: Church D.B., Small Animal Clinical Pharmacology Elsevier Health Sciences, 2008. After reading almost all of the comments on here I would think you would all exchange info and file a Class Action Lawsuit against the makers of this drug, the FDA for negligence, at least. We only hope that hes not been permanently damaged. Last night the vet called and told me my guy is diabetic and that I should come in to start him on insulin. he was bleeding internally , his lungs were inundated with blood, I will sue Zoetis, and I will make this vet live the nightmare I am living everyday, she will share my pain, because I will report her to the board of veterinarians and I am talking to the supervisors of the clinic she is in, she is the Medical Director of it , how can she be so unprofessional, and just for a couple of bucks on commission she made from selling me this poison, kill my dog. Also she was not falling down for no reason. Last week I took her off the Apoquel, out of nowhere she started eating again, even playing and drinking water. Yes, you can give your dog Apoquel and Zyrtec together. He is lethargic and seems to have aged rapidly. It especially targets the immune system. Can Apoquel be used with other medications? I called the vet and was informed to Keep her on the Apoquel and give her boiled rice and chicken for her vomiting. I gave her the boiled rice and chicken but I immediately took her off of the Apoquel and her vomiting stopped. Has anyone else has had similar issues? Early Tuesday Nov 21 my husband woke me up to tell me that Ginny had let put a help and was very weak and could not stand up on her own. But, your dog may be displaying signs of anxiety because of discomfort. After 14 days she was as if she were a puppy again. If you love your dogs please dont give them Apoquel. You are using fear tactics to prevent people from using certain medications, while then offering your own pet medications/shampoos/etc. A huge shout to today's VetGirl guest blogger is by Dr. Nicole Heinrich, DACVD of McKeever Dermatology Clinics. The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). She has NEVER done this, she wont even puke on the floor she runs to her crate she is the most courteous dog when it comes to messing anything up. Took her to my vet who did all of the blood work etc. I am pretty sure her seizures are tied in with a build up of Apoquel but its impossible to be sure. Zoetis and veterinarians should be held accountable, how can you be killing dogs with no compassion , no ethics, no nothing. I do not believe there was enough testing done on this drug. I went to the FDA website and there is not one complaint that I can find from any vet or pet owner. We are stopping the med and taking to vet tomorrow to have full blood work done. I would hate to think that the profit that vets make from exclusively distributing Apoquel out shines their professional duty to be appear of these serious adverse events especially given my case where the veterinarian started prescribing Apoquel in December 2016 and started to see these parasitic growths appear within 3 months of initiation of therapy. Apoquel can be given with or without food. among the oclacitinib group compared with placebo (2.6% vs. 0%, respectively). Use the best of all forms of proven, safe and effective methods to find underlying causes and correct them. Praying her appetite comes back and this awful abdominal swelling stops. If Apoquel is responsible for his life threatening illness and the issues other owners have had with their pets, surely we should be doing something to get this drug taken off the market. She has now had two seizures. Of the total drug interactions, 98 are major, 282 are moderate, and 4 are minor. Im convinced this drug killed my baby girl. This is the method to protect the public from unknown side effects that only appear when thousands of patients are exposed to the medication. She then proceeded to tell me that in the past week she had two dogs pass, that she suspects were from this drug. I am trying the drug today onwards for my baby and Im hoping for good results and hopefully no side effects will let you know. (every 2.5 hours). Apoquel tablets for dogs comes strengths of 3.6mg, 5.4 mg and 16mg of oclacitinib per tablet. Apoquel incidentally never stopped her itching and I will never resume the Apoquel. Antihistamines in the management of canine atopic dermatitis: a retrospective study of 171 dogs (1992-1998). We decided to continue the Apoquel until the next vet visit which was about 1 week later. The internist believes that continuing the Apoquel any further (would) wreak havoc in his immune system, that we can only expect more papilloma lesions, further inflammation of his lymph nodes, lower platelet cell cell count and so on.". I am so worried about my wee guy. My German Shepherd started on Apoquel about five months ago. God knows how he pulled through but after 5 days he was on a turn in the right direction. After reading these post Im convinced its the Apoquel. I have three Shih Tzu on Apoquel for three months. He seemed afraid to move, as if it caused him pain. For the most part hes back to being our happy, playful puppy. No episodes of stumbling. DrugBank Accession Number. I am planning on trying to wean him off the Apoquel as soon as I feel he is stable. Itching caused by an allergic skin disease can be an Just a follow up to my earlier post. A couple of weeks later, she called me and talked me into starting him on 1/2 dose as the hydroxizine wasnt working. Research has found an ingredient known as praline-rich polypeptide (PRP) in bovine colostrum; it appears to be what is helping decrease the allergy symptoms. Sounds like these side effevta most are coincidental. I always use salt water and E5 cream or take him to the sea side so he can put his paws in to the sea and it worked late time. I think they lied. Pruritus is often the result of allergies, infections, or parasites. Our dog scratches till she has raw sores on her stomach underarms and other I dont want my baby to have these terrible side effects I am reading about here. 10 percent of the dog population. My Ginny was placed in ICU to help regulate her breathing. Any advice????? I was prescribed Apoquel for my 9 yr old pug with hot spots when I told my vet that I was concerned about the possible long-term effects of using Benedryl regularly. Please never use acepromazine for dogs. They wont mind! I would say that these veterinarians are concerned about their wallets About three days later after her last dose, she was finally starting to act herself again and soon began eating out of her bowl. We have a rescue dog, 3 yrs old now. Now, in the last couple of weeks.. of going to Vet attempting to find out what is going on she actually bit a tech who stuck her face in Fendis face and startled her. I even had to duct tape socks to his feet. Zoetis, Apoquel's manufacturer, conducted a long-term (two year) study examining 247 dogs and the side effects of Apoquel they experienced. Histamines are compounds in the body which are responsible for the symptoms we experience when we are allergic to something. This year her suffering became unbearable. I thought I had found the magic drug. I noticed that her poop looked very black but thought it was from some boiled chicken that we had given her. Where do you find these complaints on the site? My vet prescribed Apoquel for her and she immediately threw up and became very listless. Drugs.com is where I found all the horrible side effects of the drug and it was too late. The vet prescribed Apoquel and after 2 weeks she never itches. I had tried hydroxyzine I think it is and now am trying the apoquel. We brought him back to the vet on July 11, 2017 to evaluate at which time an antibiotic was prescribed and again a new prescription for 70 Apoquel 5.4mg tablets at a cost of $126.00 for the Apoquel. He also had diarrhea and itching. Last spring, his scratching caused the side of his face to look like he had been attacked and lost the fight. Update on my westie. hospitalization for the diagnosis and treatment of pneumonia (after 91 days), and one dog My 7 year old Dachshund was seen my a vet for allergies that caused her ears to itch severly. Its been about 21 hours since he had a pill, so Im hoping that by tomorrow morning, its out of his system. Thank you all, positive & negative on Aproquel. We give her oatmeal baths and it dont help. I do want to note that when he first started on the apoquel, it worked really well. Yes, it stopped his itching but at what price? Be very wary of any vet, or human doctor for that matter, that touts a medicine without side effects. I was too afraid so I gave her 1/2 dose and I thought she had a mild shake. My story started a year ago last august when he scratched his jaw bloody on both sides. Just as I was dozing off, she abruptly sat up and started crying. So in the midst of all of this I did notice that her pet food had changed gradually and I finally took the last case back and put her on another food just in case it was a food additive issue! These may include vomiting, diarrhea, decreased appetite, and lethargy. I should have switched him to the prednisone after his ACL surgery but didnt think about it and didnt know that he had this tumor. He is asking to go out to pee a lot more than he used to and now has developed a smell similar to mild cat pee (no cats in our home). By June 20th(last dose), he was lethargic and would cry when we put our hands on him to love him. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. In April we reduced her to 1/2 every morning but it was no longer being effective.I raised her dosage back to1 -3.6mg a day and she started having seizures. Both need to go out more often to pee. Vet said it was not the Apoquil. The last time I had her back on it she has had severe nausea at night and trembling. My 11 Yorkie mix has had allergiesitchy feet mostly but all over at times, that we have tolerated as holisticly as possible his whole lifewith the occasional Benadryl. What drugs should not be taken with hydroxyzine? His allergies are now extreme and he has no fur on the back of his paws/legs. Thanks everyone! Expiration range: Several years. A number of different antihistamines were used. Im always sceptical of new drugs and wish I had just said no to Apoquel. I hope we stopped this drug in time before more serious damage happens. I cut the dose by half and this side effect stopped. For a sonogram and X-rays that showed everything is normal. Im just sick. He suffers from allergies also. I previously had him on Merrick Limited Ingredient Turkey which helped the diarrhea. My 8 year old beagle/basset was put on Apoquell for itching on 10/13/16 and died this morning from liver failure and pancreatitis. I was looking for a cure for the underlying cause. I encourage each and every person considering apoquel to make sure you are educated. E-mail: rfisher1951@yahoo.com On the FDA report you wrote of earlier, Apoquels side effects arent listed only their FDA approvals are there. A little research showed that the Rx was twice the recommended amount for her. She was burping, licking her mouth, eating grass and her breath smelt very bad. He was finished. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. I am grateful for tis kind of forum to be able to figure out what is wrong with our dog. Her body was like a noodle. Since it is a short-acting drug, the effects will be gone in 24 hours; however, the medication may last longer in dogs with renal or liver impairment. What do I do? Have had my 20 month old westie on it for the last two weeks. So, it is important that you only give this medication to your dog under your vets supervision. We stopped this medication as soon as we learned that she never should have been prescribed this in the first place as she had a previous cancerous tumour and also that it should not be given to a dog with a serious infection. It could be fleas or mites, a food allergy, a secondary infection (such as yeast or bacteria). It is dangerous. Her itching was better but not eliminated. The first 30 days there seemed to be no side effects, his appetite was good and it stopped the itching immediately upon the first dose he received. I took both of my dogs off of Apoquell on 01/02/17 and they are both functioning normally. Great, or so I thought. I agree. This drug is NOT a wonder drug and can kill your pet! He has woken up several times in the middle of the night to go outside and have diarrhea multiple times, then he strains and lays down on his stomach. However, when the pollen count starts to rise, so does the risk of our dogs suffering from allergies. The combination of these drugs can result in undesired side effects for your pet including vomiting and diarrhea. Shame on me for not doing my research. I never heard back because the vet told them it wasnt the Apoquil. I cannot believe his Dr. gave a medicine that might cause gastro-intestinal problems and suppress the immune system to a puppy that has a weaken immune system from mange and had recent stool and vomiting issues. The vet put him on Apoquel 16mg a day. My dog started taking Apoquel yesterday. We went to the vet because she was quite lethargic. When we told the vet we wanted to discontinue this because of the side effects she acted like she has never heard of anyone having hear issues before. Tried Benadryl which worked some, but she would get flares. I am so pleased to have Apoquel that keeps him happy and well. Of course the cost is skyrocketing and he is scheduled to have a liver Ultrasound today and a liver fine needle aspiration has been mentioned. What kind of a vet would put a dog on a drug that He walks daily and plays with is two sisters. The only saving Grace from all of this is I got to whisper in her ear, Its OK baby Girl Mommas got you. Other veterinarians may have their short comings, but at least they are more concerned about their patients and less about their wallets. My dog is much worse now and has a tumor under her forearm. Hard to articulate, more a pet parents knowing. It may be given with or without food, but giving it with food may reduce the chances of GI side effects. The day I bought the second months prescription at the cost of $105 my dog began having bloody diareah. I am a Healthcare professional and I somehow missed important information. It stops the bone marrow from manufacturing red blood cells and your pet will get very ill, which may not be able to turn around. Vet in the practice, (not her regular vet) approached me in the lobby and said she had a drug that would stop her allergies. Best regards mini stroke. I am taking my dogs off of this. for severe Gastro-Intestinal issues. I know my Dog, . Apoquel is an anti-inflammatory medication used to treat allergic dermatitis, while Zyrtec is an antihistamine used to treat allergies. We actually had to feed her out of our hand or put the food on he floor because I think she was afraid of Apoquel in her dog bowl ( yes I believe pets are smart line this). Low numbers of dogs in the studies developed demodicosis, neoplasia, pneumonia, bloody diarrhea, skin and ear infections . Had my dog on this for about a month. The first day I thought he had something stuck in his throat but since then it hasnt stopped so here I am I decided to look up the side effects and found this site. My 4 year old Yorkie was put on apoquel. There is a wide variety of reasons your dog may be itchy. no more for Her, and a new vet , too !! I will never place another animal on a medication like this again. Gabapentin is a medication that veterinarians are prescribing with increasing frequency, sometimes alone but more commonly in combination with other medications, for the management of pain in dogs. I am having the same issue as Kelly noted above. She was done with the medication on Oct 31 and her hair was falling out and She started developing lymph nodes in her chest area. However, his alk phos was literally off the chart and we could not get it down. Here are some dog owner experiences with it: http://www.2ndchance.info/Apoquel-Comments.htm. Two days after being on Apoquel, we noticed less itching. Wow!!! My dog has the latter. Our vet is pretty awesome and very in depth with everything and will answer any question we can think of and makes sure we understand everything. They may even prescribe another type of antihistamine for your dog. It contains essential fatty acids, probiotics, and colostrum, but more importantly it has helped thousands of dogs. This saved his life. So what's an antibody? Nothing worked. The vet told us anal gland problems can definitely be due to allergies. I have a St. Bernard Therapy Dog who had allergies, itching ears and feet. She is on Revolution and I have never seen a flea on her. I put him on Apoquel. I gave him a pill at 9 a.m. yesterday morning and another at 9 p.m. yesterday evening. My Vet said it looked cancerous when she aspirated it, does not mean that it is malignant but she did sound somewhat worried and talked about the way the nuclei looked under the microscope. To all dog owners WARNING do not give your dog Apoquel . In April he received Lyme vaccine and shortly thereafter developed skin infection requiring steroids. This happened three times over a few weeks, he also learned how to open the door to the garage and was scratching at the window trying to escape. I will deal with his itching in a more safe manner. Antihistamines are most often taken to relieve the symptoms of allergic reactions, such as itchiness. Hydroxyzine hydrochloride is the most common treatment for pruritus in dogs. I have also found that if we keep his paws shaved or very short that helps tremendously. The bad thing is it took away her itchingyes, it worked. He has always had allergies, some seasons are worse than others. with all I am reading, I am not sure if I will continue her on it or not. I only hope my baby Stoney will be Ok. I would have preferred using prednisone as it has worked well in the past and he didnt need to take much. It seems vets are putting dogs on it right and left, and while it may help with those symptoms..new ones develop that can be far worse. If this discomfort is due to an allergy, a skin infection, or dermatitis, your vet may prescribe an antihistamine to relieve the symptoms and make your pooch more comfortable. 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