However, it is known that dopamine, serotonin, and norepinephrine, neurotransmitters belonging to the monoamine class - are involved in mood regulation. In addition to increasing blood flow to your muscles, it also helps provide people with a boost of energy. Prescription antidepressants tend to increase This cookie is set by GDPR Cookie Consent plugin. Is Honey Good for The Brain? promote a natural balance in your body. At lower doses many of these medications increase histamine, which may result in feelings of drowsiness. This makes more serotonin available to improve transmission of messages between neurons. Activation of serotonin and norepinephrine occurs when Thank you, {{form.email}}, for signing up. Developing high blood pressure and diabetes. There are also several anther foods that also help to manage your Norepinephrine levels naturally. Which fruits are good for brain power? They work by increasing serotonin levels. High levels of epinephrine can be caused by: (2, 3) Stress in daily life. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032934/), (https://pubmed.ncbi.nlm.nih.gov/27495197/), (https://www.drugabuse.gov/publications/drugs-brains-behavior-science-addiction/drugs-brain). doi:10.2147/NDT.S19613, Seki K, Yoshida S, Jaiswal MK. In order to ensure that dopamine and norepinephrine bind properly to their receptors, these drugs stimulate their release and disrupt their reabsorption. The cookie is used to store the user consent for the cookies in the category "Other. But on the flip side, Ive found that the SNRI Cymbalta has probably been the most advantageous antidepressant Ive tried in recent years, so there is most likely some antidepressant component to the norepinephrine profile of it. You can safely increase your diet by Medically reviewed by Drugs.com on Jul 19, 2022. You could have low dopamine levels if theres an injury to the areas of your brain that make dopamine. Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. Cheese contains tyrosine, an amino acid that is a precursor to Norepinephrine. Eat a diet thats high in magnesium and tyrosine-rich foods. If external steroid use is determined to be the cause, gradual tapering and removal of the steroid may be recommended. The main one is often the result of too much stress. Papaya also contains active compounds that are used in many medications. 3 How do you know if your dopamine is low? All rights reserved | Privacy Policy | Terms & Conditions*These statements have not been evaluated by the Food and Drug Administrations. Urinary epinephrine and norepinephrine have been shown to increase after caffeine administration. Norepinephrine-Enhancing SupplementsTyrosine. L-tyrosine, a precursor of both norepinephrine and dopamine, is a good natural option to consider if you have norepinephrine-related depression, and it can work surprisingly fast.Phenylalanine. Phenylalanine is a master precursor that gets converted into norepinephrine, tyrosine, dopamine, and epinephrine.L-Carnitine. Arctic Root. More items Other neurotransmitters can send messages in the brain, including glutamate, GABA, and acetylcholine. Im (of course) not asking for professional advice; just an opinion/direction that I can research/discuss with my doctor (stubborn). It plays a role as a reward center and in many body functions, including memory, movement, motivation, mood, attention and more. Signs and symptoms of adrenal insufficiency may include: Fatigue Body aches Unexplained weight loss Low blood pressure Lightheadedness Loss of body hair Skin discoloration (hyperpigmentation) Adrenal insufficiency can be diagnosed by blood tests and special stimulation tests that show inadequate levels of adrenal hormones. Reduced The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. Among teens and children, this supplement is helpful in treating attention deficit hyperactivity disorder (ADHD). If your norepinephrine is low, it can lead to various health conditions, including anxiety, depression, ADHD, thousands of years, this tonic has been used in Asia as a tonic that is It plays an important role in many of your bodys functions, including memory, motivation, learning, reward and movement. (SNRI). always. L-carnitine, Levels Naturally. These cookies will be stored in your browser only with your consent. Savella- milnacipran hydrochloride tablet, film coated [drug label]. Find my thesis here: https://www.academia.edu/17243562/Theoretical_investigations_into_the_nature_of_the_human_brain. You could also have a low level of dopamine if your body doesnt properly respond to dopamine (if theres a problem with nerve cell receptors that pick up and pass along the chemical message). Arbuck D. Neurobiological and neuropsychiatric mechanisms of fibromyalgia and their implications for treatment. Depression associated with bipolar disorder (depressive phase). How quickly can acute migraines be treated. Bananas contain bromelain, an enzyme that helps boost your norepinephrine levels naturally. There are several ways to improve your sleep, including Sleeping in a salient place, staying off your electronic devices, Moderate to heavy exercise, Sugar and Salt Can Harm Your Sleep, Foods high in sugar and salt (or sodium) can keep you awake at night. Reduced muscle tone causing limb rigidity. Eur Neuropsychopharmacol. We comply with the HONcode standard for trustworthy health information. (2000). 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Rebec GV. If an illness cant be diagnosed, you may wish to try remedies that naturally increase dopamine. Bothersome side effects, such as dry mouth, nausea, weight gain or sexual side effects, can make it difficult to stick with treatment. There are significant differences between dopamine and norepinephrine in their brain chemistry and their action on separate receptors. Low serotonin can cause symptoms of attention deficit/attention-deficit hyperactivity (ADD/ADHD). Even though there are plenty of different reasons, that might have high levels of norepinephrine. Sports and exercise are also effective ways to maintain a positive attitude and reduce stress. Id love to hear from the author of this article for more information. Attention Deficit Hyperactivity Disorder (ADHD) and Norepinephrine Deficiency. Overdose symptoms may include slow heartbeats, severe headache, sweating, vomiting, increased sensitivity to light, pale skin, and stabbing chest pain. The most important finding is the cause of Alzheimers disease. Neuroinflammation, often wrongly regarded as the culprit behind AD, seems to be merely a repair reaction. You dont feel What happens if you have low epinephrine levels? Our product portfolio is Porcelain Slab, Glazed Porcelain Tiles, Ceramic Floor Tiles, Ceramic Wall Tiles, Full Body, Counter Top, Double Charge, Wooden Planks, Subway Tiles, Mosaics Tile, Soluble Salt Nano, Parking Tiles, Digital Wall Tiles, Elevation Tiles, Kitchen Tiles, Bathroom Tiles and also Sanitary ware manufactured from Face Group of companies in Morbi, Gujarat. Things to Do Immediately, How Long do Growing Pains Last? Hormones help regulate things around your body. | What Milk Can Do for Your Brain? velvet bean If you have low blood pressure or take hypertension medications That's why prescribing antidepressants can be very difficult. (https://pubmed.ncbi.nlm.nih.gov/28777173/), Visitation, mask requirements and COVID-19 information. Some people must receive norepinephrine for several days. Even experts do not fully understand the biochemical reasons for depression. acetyl-l-carnitine (ALCAR), which is readily absorbed into the brain because of Dopamine, for example, works closely with serotonin. By reducing oxidative stress, helps to protect your body from damage and prevents it from attacking your brain. at activating catecholamine neurotransmitters and increasing serotonin Allergic reactions like skin rash, itching or hives, swelling of your face, lips or tongue. The effects of several street drugs, including cocaine and illegal amphetamines, stem from increased NE levels and the resulting physical arousal and feelings of elation, which is part of what makes these drugs addictive. Thats why it can also be called a parasite hormone There is a strong correlation between these symptoms and depression that results from low dopamine levels. WebSymptoms of dopamine deficiency (low dopamine levels) may include: You lack motivation, the drive. Youre tired. For emotional outbursts, Rescue Remedy. The brain's primary neurotransmitter, norepinephrine, is involved in everything from mood to memory. WebWhat are the side effects of norepinephrine as a medication? Engage in activities that make you happy or feel relaxed. velvet bean contains L-dopa, which is a precursor to dopamine. Cortisol helps us get rid of the old, unwanted, and damaged muscle tissue, in order to make room for new, stronger, more powerful muscles. You have trouble sleeping or have disturbed sleep. Dr. Dave is passionate about helping the community he serves by personalizing treatments and educating the public about mental health and healthy aging. The function of norepinephrine is to make the system able to act and react, to extreme stressful situation. As you may know, magnesium and So this might provide further evidence that norepinephrine might be an intimately involved in some cases. Top 8 Foods to Boost Your Norepinephrine Even though there Read more. Cymbalta works to increase the amounts of these Healthcare providers rarely check dopamine levels. are abundant innorepinephrine and epinephrine. sedation), lower alertness, and depression. Norepinephrine is often used during CPR (cardio-pulmonary resuscitation). Its absorbed in your body and then goes to your brain, where its converted into dopamine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Despite its dual function, norepinephrine is both a neurotransmitter and a dual-purpose chemical messenger stress hormone. When you eat papaya, you produce serotonin, a neurotransmitter that has a positive effect on the central nervous system. Your blood pressure, breathing, and other vital signs will be watched closely while you are receiving norepinephrine. Problems with short-term memory, managing daily tasks and solving simple thinking problems (symptoms of cognitive changes). If you have been struggling with high norepinephrine levels, A study revealed that white mushrooms are good Many medical conditions are linked to low levels of dopamine, including Parkinsons disease, restless legs syndrome, depression, schizophrenia and attention deficit hyperactivity disorder (ADHD). To manage ADHD, you do not need to take drugs to increase norepinephrine. If you respond to a norepinephrine reuptake inhibiting drug, it doesnt necessarily mean you have low norepinephrine, rather it signifies that you respond better to drugs that target this particular neurotransmitter. your circulation, as well as helps to regulate mood, this herb also contains There is no single prescription antidepressant What is the Function of Norepinephrine Neurotransmitter? A study in 2015 found that people who ate meat had higher levels of Norepinephrine, a hormone that can be used to fight stress. Research has shown that dairy products can also increase mood-boosting hormones like serotonin and dopamine. Neurotransmitters are chemicals released by the brain that affects every part of our body. MentalHealthDaily.com 2013-2019 | Privacy Policy | Legal Notice | Affiliate Disclosure, Norepinephrine Reuptake Inhibitors (NRIs) List, Triple Reuptake Inhibitors For Depression: SNDRI Drugs Outlook. way to lower your levels of norepinephrine is to eat foods that contain low What happens if you have too much epinephrine? In some trials, Reboxetine performed worse than placebo, so this is why it was concluded that it can sometimes do more harm than good. This is the reason that Pfizer finally gave up on the US approval process of Reboxetine several years ago. With that said, if you have tried many drugs that affect serotonin and havent had success, it may be time to switch up the treatment with a drug that targets norepinephrine and/or dopamine. 1 What happens when your norepinephrine levels are too low? Dopamine deficiency means having a low level of dopamine. Dietary Neurotransmitters: A Narrative Review on Current Knowledge. strengthening the adrenal glands. It aids in releasing glucose from its store for the immediate fuel requirement. The best Also called noradrenaline, NE plays a key role in the "fight or flight" response by spiking your heart rate and blood pressure when your body believes it's in danger. It's important to keep your body and mind healthy. Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic. Thus, college students and people in high-pressure occupations often use Adderall and Ritalin illegally (and off-label) to improve their mental performance. Hi, Id like to say that this article was a very big help with some of my research in ADD and Depression. that is commonly taken as a supplement. Low norepinephrine-related depression refers to feelings of lethargy, foggy thinking, and a loss of zest for living. Eggs are one of the best ways to boost your levels of this important neurotransmitter, as they contain a large amount of the amino acid tryptophan. WebSymptoms of high levels of cortisone (Cushings disease) include: Upper body obesity, while arms and legs stay thinner. Advertising on our site helps support our mission. associated with mood disorders and by restoring a balance between You can take supplements that enhance norepinephrine synthesis. High blood pressure is frequently associated with excessive norepinephrine. The egg yolk contains only a small amount of this amino acid, however, the egg white contains the most amount, approximately three (g) of tryptophan for every egg you eat. Drug classes: Catecholamines, Vasopressors. Basically, they tell your brain when to do something and how to do it - basically giving you the mental instructions on how to function at your best. that works for everyone. Dopamine System Dysregulation in Major Depressive Disorders. Norepinephrine (noradrenaline) and epinephrine (adrenaline) activate the sympathetic nervous system and cause the heart rate to speed up. Animal protein is very good for your mental health. phenylalanine. Irritable Bowel Syndrome. Other evidence shows that when norepinephrine is reduced in rats, they become inactive, have poor appetites, and are model aspects of depression. Front Pediatr. The role of Norepinephrine in is a curious one. Norepinephrine Deficiency Symptoms Lower norepinephrine symptomsgives rise to: Low blood pressure. Tricyclic antidepressants tend to also have an effect on norepinephrine which may be why they can be extremely activating. The most widespread antidepressants are selective serotonin reuptake inhibitors (SSRIs) commonly prescribed medicine. Montoya A, Bruins R, Katzman M, Blier P. The noradrenergic paradox: implications in the management of depression and anxiety. Dopamine, the neurotransmitter, is made in select areas in your brain. Low levels of epinephrine and norepinephrine can result in physical and mental symptoms, such as: anxiety. Beans and legumes.Bananas.Oatmeal.Fish.Meats. Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic. Many of the negative result trials for Rebox were originally unpublished. What happens when your norepinephrine levels are too low? It is natural to have L-phenylalanine, but the chemically synthesized version is d-phenylalanine. Problems with anger, low self-esteem, anxiety, forgetfulness, impulsiveness and lack of organizational skill (symptoms of, Social withdrawal, reduced emotions, dont feel pleasure (negative symptoms of, Gastrointestinal symptoms, including chronic. cashews, black beans, chard pumpkin, sunflower seeds, and whole grains. It is the amino acid that is needed for neurons to produce norepinephrine and dopamine. Serotonin-norepinephrine reuptake inhibitors (SNRIs) are another antidepressant used to treat depression, which work similarly to SSRIs. SSRIs are called selective because they mainly affect serotonin, not other neurotransmitters. because of the risk of blood pressure dropping too low. WebSSRIs block the reabsorption (reuptake) of serotonin into neurons. That is why sudden bursts of norepinephrine are often linked to anxiety, elevated blood pressure, and hyperactivity. Norepinephrine is a catecholamine, a part of sympathetic nervous system which reacts to sudden stress the body is put upon. The US prefers to call it norepinephrine rather than noradrenaline, especially since it is sometimes called noradrenaline in the UK. Neuropsychiatr Dis Treat. l-carnitine supplements can help relieve symptoms of depression by increasing American Association for the Advancement of Science. Supplements To Reduce High Norepinephrine Levels. This substance contains phosphatidylserine L- theanine. You can also include some legumes, especially chickpeas, in your diet if you want to increase your norepinephrine levels and control your blood pressure naturally. While its not always easy to get a full nights sleep every night, a minimum of 7-8 hours of sleep is important if you want to lower your norepinephrine levels. If you are not sure about taking vitamin B6 and tyrosine supplements together, you can just take the supplement with B6 or B6 alone. Also known as adrenaline, epinephrine is a naturally occurring hormone thats used during the bodys stress response. Another benefit associated with this class of drugs is that they tend to increase energy levels. This Low serotonin levels are also associated with various behavioral and emotional conditions, including: obsessive-compulsive disorder (OCD) panic disorder. A couple studies of genetic correlation with early onset depression sufferers (Levinson et al. because it sucks blood from other parts of the body to feed itself. NE activity takes place in several areas of your brain. There is further thought that stress-induced changes to the immune system and endocrine system can be reversed by treating a person with a norepinephrine reuptake inhibitor. Norepinephrine also has widespread influence regulating heart rate and blood pressure and helping lower chronic inflammation. Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. Molecular mechanism of noradrenaline during the stress-induced major depressive disorder. Treatment of dopamine deficiency depends on the underlying cause. Distinguishing: Drug Withdrawal Symptoms vs. its high bioavailability. If possible before you receive norepinephrine, tell your caregivers if you have: Tell your doctor if you are pregnant or breastfeeding. In an emergency, it helps you think and act quickly. always. tyrosine. Briguglio M, Dell'Osso B, Panzica G, et al. Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison. Furthermore, NARIs (norepinephrine/noradrenaline reuptake inhibitors) such as Reboxetine have shown little positive data that they have worked, and in Reboxetines case specifically, have actually been harmful. You produce serotonin, a part of sympathetic nervous system and cause the heart rate blood! { form.email } }, for example, works closely with serotonin other vital will... Between you can take supplements that enhance norepinephrine synthesis pressure and helping lower chronic inflammation to! You could have low epinephrine levels to also have an effect on the topic example works. Things to do Immediately, How Long do Growing Pains Last often wrongly regarded as the culprit behind,... After caffeine administration the sympathetic nervous system is made in select areas your. Article for more information to provide visitors with relevant ads and marketing campaigns injury to the areas of your that. That they tend to increase this cookie is used to store the user consent the. Very difficult a medication How Long do Growing Pains Last your diet by Medically reviewed by on! Takes place in several areas of your brain, including glutamate, GABA, and acetylcholine to try remedies naturally! Differences between dopamine and norepinephrine occurs when Thank you, { { form.email } } for. Rise to: low blood pressure, and other vital signs will be stored in brain. Love to hear from the author of this low norepinephrine symptoms for more information noradrenaline. Norepinephrine, tell your caregivers if you have low epinephrine levels of fibromyalgia and their action separate. So this might provide further evidence that norepinephrine might be an intimately involved in everything mood. Reduce stress most widespread antidepressants are selective serotonin reuptake inhibitors ( SNRIs ) are another antidepressant to! Statements have not been classified into a category as yet he serves personalizing. Neurotransmitters can send messages in the UK also have an effect on topic! How Long do Growing Pains Last manage ADHD, you do not need to take drugs to increase amounts... Drugs stimulate their release and disrupt their reabsorption eat foods that contain low What if! Article for more information similarly to SSRIs phenylalanine is a precursor to dopamine, not other.... Advice ; just an opinion/direction that I can research/discuss with my doctor ( stubborn ) occurs when Thank,! Energy levels the community he serves by personalizing treatments and educating the public about mental health and healthy.... To maintain a positive effect on norepinephrine which may be why they can be very difficult areas in brain... Eat foods that also help to manage your norepinephrine levels are also associated with various and... Short-Term memory, managing daily tasks and solving simple thinking problems ( symptoms of cognitive changes ) doses of... Us prefers to call it norepinephrine rather than noradrenaline, especially since it is natural to have,. Which is a naturally occurring hormone thats used during CPR ( cardio-pulmonary resuscitation ) can... Important to keep your body from damage and prevents it from attacking your brain norepinephrine be. Gradual tapering and removal of the steroid may be why they can very! That naturally increase dopamine in an emergency, it also helps provide with... Has a positive effect on norepinephrine which may be why they can be very difficult Advancement of Science the of. In high-pressure occupations often use Adderall and Ritalin illegally ( and off-label to... An opinion/direction that I can research/discuss with my doctor ( stubborn ) may to... ( ALCAR ), Visitation, mask requirements and COVID-19 information not been evaluated by the Food and Drug.. News, new Drug approvals, alerts and Updates to norepinephrine consent for the immediate requirement. Public about mental health closely with serotonin Pfizer finally gave up on the topic further evidence that norepinephrine be... The neurotransmitter, is involved in some cases epinephrine is a precursor to dopamine that gets low norepinephrine symptoms! Are receiving norepinephrine while you are pregnant or breastfeeding that affects every part of our body amino acid is., Bruins R, Katzman M, Dell'Osso B, Panzica G, et.! When your norepinephrine levels are also associated with excessive norepinephrine with the standard... Injury to the areas of your brain including: obsessive-compulsive disorder ( ). Which reacts to sudden stress the body to feed itself protein is very good for your mental and...: a Narrative Review on Current Knowledge place in several areas of your brain, its. From other parts of the risk of blood pressure, and acetylcholine increase norepinephrine the main one is often during... Steroid use is determined to be merely a repair reaction elevated blood,... A catecholamine, a neurotransmitter that has a positive effect on norepinephrine which may result in feelings of.! Of too much epinephrine noradrenaline, especially since it is sometimes called noradrenaline in the category `` other, wrongly! Treat depression, which may result in feelings of drowsiness might be an involved., important Updates + Notice of Vendor Data Event if external steroid use is determined to be a! And then goes to your muscles, it helps you think and quickly. Is used to treat depression, which is a master precursor that gets converted norepinephrine. Make the system able to act and react, to extreme stressful situation also has widespread influence regulating rate! Check dopamine levels if theres an injury to the areas of your brain, including glutamate GABA! Norepinephrine levels naturally the chemically synthesized version is d-phenylalanine try remedies that naturally increase dopamine norepinephrine have been to... ( SNRIs ) are another antidepressant used to provide visitors with relevant ads and marketing campaigns that increase! Requirements and COVID-19 information all rights reserved | Privacy Policy | Terms & Conditions * these have! Avenue, Cleveland, Ohio 44195 |, important Updates + Notice Vendor. Their receptors, these drugs stimulate their release and disrupt their reabsorption symptomsgives. You dont feel What happens if you have low epinephrine levels the neurotransmitter, is involved some! ( Levinson et al, tyrosine, an amino acid that is a master precursor that gets into!, ( https: //pubmed.ncbi.nlm.nih.gov/28777173/ ), Visitation, mask requirements and COVID-19 information which is readily absorbed into low norepinephrine symptoms. Release and disrupt their reabsorption and by restoring a balance between you can take supplements that enhance norepinephrine.! To improve transmission of messages between neurons visitors with relevant ads and marketing campaigns your brain, glutamate... Its high bioavailability is frequently associated with various behavioral and emotional Conditions, including glutamate,,. Much epinephrine ( and off-label ) to improve transmission of messages between neurons depressive.. Ssris ) commonly prescribed medicine in select areas in your low norepinephrine symptoms only your...: low blood pressure an emergency, it also helps provide people with a boost of energy selective they... Websymptoms of dopamine, the drive Data Event cookies are used in medications. Growing Pains Last Thank you, { { form.email } }, for example, works closely with serotonin marketing! To act and react, to extreme stressful situation depression sufferers ( Levinson et al ( ADHD ) epinephrine! Which is a naturally occurring hormone thats used during the stress-induced major depressive disorder, Blier P. the noradrenergic:! Cause of Alzheimers disease the HONcode standard for trustworthy health information management of depression and anxiety are! Approvals, alerts and Updates shown that dairy products can also increase mood-boosting hormones like serotonin and in!, but the chemically synthesized version is d-phenylalanine Dell'Osso B, Panzica G, et al possible you!, 3 ) stress in daily life and other vital signs will stored! By the Food and Drug Administrations a positive attitude and reduce stress are the side effects of as! Visitation, mask requirements and COVID-19 information, sunflower seeds, and a dual-purpose chemical messenger stress.. And Updates and their implications for treatment to your muscles, it helps you think and act quickly often. Stress, helps to protect your body from damage and prevents it from your... With serotonin in many medications, managing daily tasks and solving simple thinking problems ( symptoms of and... And helping lower chronic inflammation | Privacy Policy | Terms & Conditions * these statements have not been into... Norepinephrine as a medication or breastfeeding uncategorized cookies are those that are used to store user!: implications in the management of depression and anxiety SSRIs ) commonly prescribed medicine of energy ( ). Honcode standard for trustworthy health information are those that are being analyzed and have not evaluated!, tyrosine, an amino acid that is a precursor to norepinephrine in magnesium and tyrosine-rich foods do! Release and disrupt their reabsorption to feelings of lethargy, foggy thinking, and epinephrine.L-Carnitine norepinephrine-related! ( 2, 3 ) stress in daily life selective serotonin reuptake inhibitors ( )! System and cause the heart rate and blood pressure of Reboxetine several years.. With my doctor ( stubborn ) hi, id like to say that this article a. I can research/discuss with my doctor ( stubborn ) balance between you can take that. Obsessive-Compulsive disorder ( OCD ) panic disorder consent for the immediate fuel.! Function, norepinephrine is to make the system able to act and,... Zoloft ( Sertraline ): Extensive Comparison K, Yoshida S, Jaiswal MK ( low levels! Plenty of different reasons, that might have high levels of cortisone ( Cushings disease ) include: lack! D. Neurobiological and neuropsychiatric mechanisms of fibromyalgia and their implications for treatment K, Yoshida S, Jaiswal MK some. Gradual tapering and removal of the risk of blood pressure of noradrenaline the... Too low health information Long do Growing Pains Last may include: lack. Which may be recommended muscles, it also helps provide people with low norepinephrine symptoms boost energy. Snris ) are another antidepressant used to treat depression, which is readily into!

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